2. Academic Validation
  3. The identification and optimization of 2,4-diketobutyric acids as flap endonuclease 1 inhibitors

The identification and optimization of 2,4-diketobutyric acids as flap endonuclease 1 inhibitors

  • Bioorg Med Chem Lett. 2004 Oct 4;14(19):4915-8. doi: 10.1016/j.bmcl.2004.07.028.
L Nathan Tumey 1,  Bayard Huck,  Elizabeth Gleason,  Jianmin Wang,  Daniel Silver,  Kurt Brunden,  Sherry Boozer,  Stephen Rundlett,  Bruce Sherf,  Steven Murphy,  Andrew Bailey,  Tom Dent,  Christina Leventhal,  John Harrington,  Youssef L Bennani
Affiliations

Affiliation

  • 1 Athersys, Inc., 3201 Carnegie Ave., Cleveland, OH 44115, USA. ntumey@athersys.com
PMID: 15341951 DOI: 10.1016/j.bmcl.2004.07.028
Abstract

There have been several recent reports of chemopotentiation via inhibition of DNA repair processes. Flap Endonuclease 1 (FEN1) is a key enzyme involved in base excision repair (BER), a primary pathway utilized by mammalian cells to repair DNA damage. In this report, we describe the identification and SAR of a series of 2,4-diketobutyric acid FEN1 inhibitors.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-185455
    FEN1抑制剂
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