2. Academic Validation
  3. Effectiveness of propagermanium treatment in multiple myeloma patients

Effectiveness of propagermanium treatment in multiple myeloma patients

  • Eur J Haematol. 2004 Dec;73(6):397-401. doi: 10.1111/j.1600-0609.2004.00330.x.
Yutaka Tsutsumi 1,  Junji Tanaka,  Hiroe Kanamori,  Mio Musashi,  Hiina Minami,  Arata Fukushima,  Hiroaki Yamato,  Nobuyuki Ehira,  Takahito Kawamura,  Shinji Obara,  Nobutaka Ogura,  Masahiro Asaka,  Masahiro Imamura,  Nobuo Masauzi
Affiliations

Affiliation

  • 1 Department of Internal Medicine, Hakodate Municipal Hospital, Hakodate, Japan. rtsutsu@nyc.odn.ne.jp
PMID: 15522060 DOI: 10.1111/j.1600-0609.2004.00330.x
Abstract

Interferon (IFN) is one of several drugs effective in treating multiple myeloma (MM), and propagermanium is an IFN inducer. We report on 10 MM patients who were treated with propagermanium at doses from 10 to 40 mg. Two patients achieved complete remission (CR), two patients achieved partial remission (PR), and the condition of four patients was stable (stable disease, SD). After discontinuation of propagermanium, the status of MM progressed in two patients who were in SD and in two patients who had achieved PR. The administration of propagermanium was restarted in one patient resulting in a decrease in her paraprotein.

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