2. Academic Validation
  3. Design, synthesis and biological evaluation of novel, simplified analogues of laulimalide: modification of the side chain

Design, synthesis and biological evaluation of novel, simplified analogues of laulimalide: modification of the side chain

  • Bioorg Med Chem Lett. 2005 May 2;15(9):2243-7. doi: 10.1016/j.bmcl.2005.03.018.
Ian Paterson 1,  Dirk Menche,  Anders E Håkansson,  Adrian Longstaff,  David Wong,  Isabel Barasoain,  Rubén M Buey,  J Fernando Díaz
Affiliations

Affiliation

  • 1 University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK, EU. ip100@cam.ac.uk
PMID: 15837302 DOI: 10.1016/j.bmcl.2005.03.018
Abstract

Novel, simplified analogues of the microtubule-stabilizing Anticancer agent laulimalide, including the first derivatives with unnatural side chains, were designed by molecular modelling, synthesized by a late-stage diversification strategy, and evaluated in vitro for growth inhibition of human ovarian carcinoma cell lines (A2780, A2780/AD10).

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