2. Academic Validation
  3. Antitubercular constituents from the stem wood of Cinnamomum kotoense

Antitubercular constituents from the stem wood of Cinnamomum kotoense

  • J Nat Prod. 2005 Sep;68(9):1318-23. doi: 10.1021/np0580210.
Fu-Chi Chen 1,  Chien-Fang Peng,  Ian-Lih Tsai,  Ih-Sheng Chen
Affiliations

Affiliation

  • 1 Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China.
PMID: 16180806 DOI: 10.1021/np0580210
Abstract

Five new compounds, kotolactone A (1), kotolactone B (2), secokotomolide (3), kotodiol (4), and 2-acetyl-5-dodecylfuran (5), and 36 known compounds have been isolated from the stem wood of Cinnamomum kotoense. The structures of these new compounds were determined by means of spectroscopic analysis. The known butanolides, isoobtusilactone A (6) and lincomolide B (7), showed in vitro antitubercular activities with MIC values of 22.48 and 10.16 microM, respectively, against Mycobacterium tuberculosis 90-221387.

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