2. Academic Validation
  3. A concise synthesis of ginkgolide M, a minor component of a terpene trilactone fraction from ginkgo biloba roots

A concise synthesis of ginkgolide M, a minor component of a terpene trilactone fraction from ginkgo biloba roots

  • J Nat Prod. 2006 Mar;69(3):429-31. doi: 10.1021/np050403i.
Sergei Bolshakov 1,  Sergei V Dzyuba,  John Decatur,  Koji Nakanishi
Affiliations

Affiliation

  • 1 Department of Chemistry, Columbia University, New York, New York 10027, USA.
PMID: 16562852 DOI: 10.1021/np050403i
Abstract

Ginkgolide M (GM), which is found only in the roots of the Ginkgo biloba tree and is an inhibitor of ligand-operated ion channels in the central nervous system, has been prepared in three steps from 10-benzylginkgolide C, an intermediate generated during the isolation and separation of ginkgolides from Ginkgo biloba leaf extract. The described synthetic sequence can be applied to access GM derivatives for biological studies.

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