2. Academic Validation
  3. 3,3'-dipyridyl BINOL ligands. Synthesis and application in enantioselective addition of Et2Zn to aldehydes

3,3'-dipyridyl BINOL ligands. Synthesis and application in enantioselective addition of Et2Zn to aldehydes

  • Org Lett. 2007 Oct 25;9(22):4403-6. doi: 10.1021/ol071276f.
Robert R Milburn 1,  S M Shakil Hussain,  Olaf Prien,  Zaheer Ahmed,  Victor Snieckus
Affiliations

Affiliation

  • 1 Department of Chemistry, Queen's University, Kingston, Ontario, Canada K7L 3N6.
PMID: 17900193 DOI: 10.1021/ol071276f
Abstract

3,3'-di(2-pyridyl) BINOLs (4), prepared in three steps from commercial substances by a combined directed ortho metalation-Negishi cross-coupling protocol, constitute new members of the BINOL ligand family. They are among the most selective, general ligands, providing equal or greater stereoselectivities in the Et2Zn addition to benzaldehydes and cinnamaldehydes (Table 3) than any single BINOL ligand reported to date.

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