2. Academic Validation
  3. Synthesis and cytotoxicity evaluation of some benzimidazole-4,7-diones as bioreductive anticancer agents

Synthesis and cytotoxicity evaluation of some benzimidazole-4,7-diones as bioreductive anticancer agents

  • Eur J Med Chem. 2008 Sep;43(9):1858-64. doi: 10.1016/j.ejmech.2007.11.020.
Armand Gellis 1,  Hervé Kovacic,  Narimène Boufatah,  Patrice Vanelle
Affiliations

Affiliation

  • 1 Laboratoire de Chimie Organique Pharmaceutique, UMR CNRS 6517, Université de la Méditerranée, Faculté de Pharmacie, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France.
PMID: 18222567 DOI: 10.1016/j.ejmech.2007.11.020
Abstract

New benzimidazole-4,7-diones substituted at 2-position were synthesized via a microwave-assisted reaction using 2-chloromethyl-1,5,6-trimethyl-1H-benzimidazole-4,7-dione 5b as a key intermediate compound. Their cytotoxicity has been evaluated on colon, breast and lung Cancer cell lines. The dimer 17 was shown to possess excellent cytotoxicity comparable to that of mitomycin C.

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