2. Academic Validation
  3. Discovery of conformationally rigid 3-azabicyclo[3.1.0]hexane-derived dipeptidyl peptidase-IV inhibitors

Discovery of conformationally rigid 3-azabicyclo[3.1.0]hexane-derived dipeptidyl peptidase-IV inhibitors

  • Bioorg Med Chem Lett. 2008 Jul 15;18(14):4087-91. doi: 10.1016/j.bmcl.2008.05.101.
Jitendra A Sattigeri 1,  Murugaiah M S Andappan,  Kaushal Kishore,  Srinivasan Thangathirupathy,  Sinduja Sundaram,  Shuchita Singh,  Suchitra Sharma,  Joseph A Davis,  Anita Chugh,  Vinay S Bansal
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Ranbaxy Research Laboratories, Gurgaon 122001, India. jitendra.sattigeri@ranbaxy.com
PMID: 18602260 DOI: 10.1016/j.bmcl.2008.05.101
Abstract

The induction of conformationally restricted N-(aryl or heteroaryl)-3-azabicyclo[3.1.0]hexane derivatives at P(2) region of compounds of 2-cyanopyrrolidine class was explored to develop novel DPP-IV inhibitors. The synthesis, structure-activity relationship, and selectivity against related proteases are delineated.

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