2. Academic Validation
  3. Pyrrolizidine alkaloids from Echium glomeratum (Boraginaceae)

Pyrrolizidine alkaloids from Echium glomeratum (Boraginaceae)

  • Phytochemistry. 2008 Sep;69(12):2341-6. doi: 10.1016/j.phytochem.2008.06.017.
Feras Q Alali 1,  Yahya R Tahboub,  Eyad S Ibrahim,  Amjad M Qandil,  Khaled Tawaha,  Jason P Burgess,  Arlene Sy,  Yuka Nakanishi,  David J Kroll,  Nicholas H Oberlies
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan. falali@just.edu.jo
PMID: 18691727 DOI: 10.1016/j.phytochem.2008.06.017
Abstract

The methanolic extract of the whole plant of Echium glomeratum Poir. (Boraginaceae) has afforded five Pyrrolizidine Alkaloids, three that were (7S, 8R)-petranine (1), (7S, 8S)-petranine (2), and (7R, 8R)-petranine (3a) or (7R, 8S)-petranine (3b), comprising a tricyclic Pyrrolizidine Alkaloids subclass; and two that were known but to the species: 7-angeloylretronecine (4) and 9-angeloylretronecine (5). All compounds were tested against a human tumor panel for cytotoxicity; no activity was observed (EC50 values>20microg/ml).

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z