2. Academic Validation
  3. New Labdane diterpenes as intestinal alpha-glucosidase inhibitor from antihyperglycemic extract of Hedychium spicatum (Ham. Ex Smith) rhizomes

New Labdane diterpenes as intestinal alpha-glucosidase inhibitor from antihyperglycemic extract of Hedychium spicatum (Ham. Ex Smith) rhizomes

  • Bioorg Med Chem Lett. 2009 May 1;19(9):2562-5. doi: 10.1016/j.bmcl.2009.03.045.
P Prabhakar Reddy 1,  Ashok K Tiwari,  R Ranga Rao,  K Madhusudhana,  V Rama Subba Rao,  Amtul Z Ali,  K Suresh Babu,  J Madhusudana Rao
Affiliations

Affiliation

  • 1 Natural Products Laboratory, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500 607, India.
PMID: 19332371 DOI: 10.1016/j.bmcl.2009.03.045
Abstract

Phytochemical investigation of antihyperglycemic extract of rhizomes of Hedychium spicatum led to the isolation of two new labdane type diterpenes 2, 3 along with seven known compounds (1, 4-9). Their structures were established on the basis of NMR (1D and 2D) and mass spectroscopic analysis. The new compound 2 displayed strong intestinal alpha-glucosidase inhibitory activity. Other compounds also displayed varying degree of intestinal alpha-glucosidase inhibitory potential.

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