1. Academic Validation
  2. Absolute stereostructures of olibanumols A, B, C, H, I, and J from olibanum, gum-resin of Boswellia carterii, and inhibitors of nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages

Absolute stereostructures of olibanumols A, B, C, H, I, and J from olibanum, gum-resin of Boswellia carterii, and inhibitors of nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages

  • Chem Pharm Bull (Tokyo). 2009 Sep;57(9):957-64. doi: 10.1248/cpb.57.957.
Masayuki Yoshikawa 1 Toshio Morikawa Hideo Oominami Hisashi Matsuda
Affiliations

Affiliation

  • 1 Kyoto Pharmaceutical University, Japan. myoshika@mb.kyoto-phu.ac.jp
Abstract

Three new monoterpenes, olibanumols A (1), B (2), and C (3), and three new Triterpenes, olibanumols H (4), I (5), and J (6), were isolated from olibanum, the exuded gum-resin from Boswellia carterii BIRDW. Their structures including the absolute configuration were determined by chemical and physicochemical evidence. Among the constituents, olibanumols A (1), H (4), and I (5), and isofouquierol (12) exhibited nitric oxide production inhibitory activity in lipopolysaccharide-activated mouse peritoneal macrophages.

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