2. Academic Validation
  3. Centrally administered nesfatin-1 inhibits feeding behaviour and gastroduodenal motility in mice

Centrally administered nesfatin-1 inhibits feeding behaviour and gastroduodenal motility in mice

  • Neuroreport. 2010 Oct 27;21(15):1008-11. doi: 10.1097/WNR.0b013e32833f7b96.
Kaori Atsuchi 1,  Akihiro Asakawa,  Miharu Ushikai,  Koji Ataka,  Minglun Tsai,  Kenichiro Koyama,  Yuki Sato,  Ikuo Kato,  Mineko Fujimiya,  Akio Inui
Affiliations

Affiliation

  • 1 Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
PMID: 20827224 DOI: 10.1097/WNR.0b013e32833f7b96
Abstract

Nesfatin-1 was recently identified as a peptide with anorexigenic effects that is localized in the hypothalamus and adipocytes. Not much is known about the effect of nesfatin-1 on gut motility. Food intake was measured after intracerebroventricular administration of nesfatin-1 in food-deprived mice. Antral and duodenal motility was assessed by using a manometric method in conscious fed mice. We found that centrally administered nesfatin-1 decreased food intake and inhibited gastroduodenal motility in mice. These results suggest that nesfatin-1 influences gut motility and feeding behaviour.

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