2. Academic Validation
  3. Placental Alkaline Phosphatase (PLAP) Luminescent HTS assay - Probe 1

Placental Alkaline Phosphatase (PLAP) Luminescent HTS assay - Probe 1

Eduard Sergienko,  Xochella Garcia,  Brock Brown,  Justin Rascon,  Sonoko Narisawa,  Ana Maria Simao,  José Luis Millán,  Derek Stonich,  Ying Su,  Pasha Khan,  Greg Roth,  Layton Smith,  Shakeela Dad,  Thomas DY Chung,  Nicholas DP Cosford
PMID: 21433359
Abstract

Placental Alkaline Phosphatase (PLAP) is highly expressed in primate placental tissue. Its biological function and relevance are still unknown, but PLAP-like Enzymes are detected in serum of patients with primary testicular tumors, in particular seminoma and Other cancers. Consequently, the identification of PLAP-specific inhibitors with selectivity over tissue non-specific Alkaline Phosphatase (TNAP) and intestinal Alkaline Phosphatase (IAP) may provide the necessary tools to characterize its biological role. Currently, inhibitors of PLAP lack either potency or selectivity. The small molecule probe ML085 (CID-25067483) is a biochemical inhibitor of PLAP, and will be useful to elucidate the key biological functions and natural substrates of human PLAP.

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