2. Academic Validation
  3. Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles

Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles

  • Bioorg Med Chem Lett. 2012 May 1;22(9):3362-5. doi: 10.1016/j.bmcl.2012.02.035.
Willmen Youngsaye 1,  Chris Dockendorff,  Benjamin Vincent,  Cathy L Hartland,  Joshua A Bittker,  Sivaraman Dandapani,  Michelle Palmer,  Luke Whitesell,  Susan Lindquist,  Stuart L Schreiber,  Benito Munoz
Affiliations

Affiliation

  • 1 Chemical Biology Platform and Probe Development Center, Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.
PMID: 22497765 DOI: 10.1016/j.bmcl.2012.02.035
Abstract

Continuing efforts to discover novel means of combating fluconazole resistance in Candida albicans have identified an indole derivative that sensitizes strains demonstrating resistance to fluconazole. This tetracycle (3, ML229) does not appear to act through established HSP90 or Calcineurin pathways to chemosensitize C. albicans, as determined in Saccharomyces cerevisiae models, and may be a useful probe to uncover alternative resistance pathways.

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