2. Academic Validation
  3. Chemical constituents of Abies delavayi

Chemical constituents of Abies delavayi

  • Phytochemistry. 2014 Sep:105:164-70. doi: 10.1016/j.phytochem.2014.05.012.
Xian-Wen Yang 1,  Su-Mei Li 2,  Yong-Li Li 3,  Lin Feng 3,  Yun-Heng Shen 3,  Shen Lin 3,  Jun-Mian Tian 3,  Hua-Wu Zeng 3,  Ning Wang 4,  Andre Steinmetz 4,  Yonghong Liu 2,  Wei-Dong Zhang 5
Affiliations

Affiliations

  • 1 Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, China; Key Laboratory of Marine Bio-Resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, China; Luxembourg Public Research Centre for Health (CRP-SANTE), 84 Val Fleuri, L-1526 Luxembourg, Luxembourg.
  • 2 Key Laboratory of Marine Bio-Resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, China.
  • 3 Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, China.
  • 4 Luxembourg Public Research Centre for Health (CRP-SANTE), 84 Val Fleuri, L-1526 Luxembourg, Luxembourg.
  • 5 Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, China. Electronic address: wdzhangy@hotmail.com.
PMID: 24916321 DOI: 10.1016/j.phytochem.2014.05.012
Abstract

Systematic phytochemical investigations on Abies delavayi afforded 110 compounds, including 49 Terpenoids, 13 Lignans, 20 Flavonoids, three Coumarins, and 25 Other chemical constituents. By detailed analysis of one- and two-dimensional NMR spectroscopic and high-resolution mass spectrometric data, 10 previously unreported compounds were identified: they comprised three sesquiterpenoids, two Diterpenoids, one triterpenoid, one monoterpenoid, one flavonoid, and two Phenols. These 10 compounds and some previously known ones were subjected to two cytotoxic bioassays against three human tumor cell lines and NO production inhibition on RAW264.7 macrophages, respectively. (25R)-24,25-Dihydroabieslactone had the strongest cytotoxic activity against Colo-205 cells with an IC50 value of 19.0±3.7μg/mL. (+)-T-cadinol, 8,11,13-abietatrien-15-ol-18-yl acetate, 18-acetoxy-13-epi-manool, imperatorin, bergapten, and 5,7-O-dimethyl poriol exhibited weak inhibitory activity against LPS-induced NO production in RAW264.7 macrophages with IC50 values of approximately 50μg/mL.

Keywords

Abies delavayi; Cytotoxicity; Monoterpenes; Nitric oxide (NO); Phenols; Pinaceae; Sesquiterpenes; Triterpenoids.

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