2. Academic Validation
  3. Synthesis of unsymmetrical pyrazines based on α-diazo oxime ethers

Synthesis of unsymmetrical pyrazines based on α-diazo oxime ethers

  • Org Lett. 2015 Feb 6;17(3):395-7. doi: 10.1021/ol5034173.
Nicole S Y Loy 1,  Sunggak Kim,  Cheol-Min Park
Affiliations

Affiliation

  • 1 Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University , Singapore 637616, Singapore.
PMID: 25590992 DOI: 10.1021/ol5034173
Abstract

Synthesis of unsymmetrically substituted pyrazines has been a challenge. The reactivity of α-imino carbenoids derived from α-diazo oxime ethers has been exploited for pyrazine synthesis, in which the reaction of α-diazo oxime ethers with 2H-azirines provides highly substituted pyrazines in good to excellent yields.

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