2. Academic Validation
  3. In vitro evaluation of the antibiofilm properties of chlorhexidine and delmopinol on dental implant surfaces

In vitro evaluation of the antibiofilm properties of chlorhexidine and delmopinol on dental implant surfaces

  • Int J Antimicrob Agents. 2015 Jun;45(6):662-6. doi: 10.1016/j.ijantimicag.2015.01.020.
Derren Ready 1,  Georgios Theodoridis 2,  Ingrid Green 3,  Lena Ciric 2,  Jonathan Pratten 2,  Weiming Tay 4,  Ailbhe McDonald 5
Affiliations

Affiliations

  • 1 Public Health England, PHL London, 3rd Floor Pathology & Pharmacy Building, 80 Newark Street, London E1 2ES, UK; Microbiology Unit, Eastman Dental Hospital, UCLH NHS Foundation Trust, 256 Gray's Inn Road, London WC1X 8LD, UK. Electronic address: derren.ready@phe.gov.uk.
  • 2 Department of Microbial Diseases, UCL Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, UK.
  • 3 Microbiology Unit, Eastman Dental Hospital, UCLH NHS Foundation Trust, 256 Gray's Inn Road, London WC1X 8LD, UK; Department of Microbial Diseases, UCL Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, UK.
  • 4 Continuing Professional Development, UCL Eastman Dental Institute, 123 Gray's Inn Road, London WC1X 8WD, UK.
  • 5 Department of Prosthodontics, UCL Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, UK.
PMID: 25963339 DOI: 10.1016/j.ijantimicag.2015.01.020
Abstract

Biofilm development on the internal surfaces of dental implants and dental implant components may be associated with peri-implant hard and soft tissue abnormalities. Currently, no protocols have been established for effective disinfection of removable implant components. The purpose of this study was to evaluate the antibiofilm properties of commonly used dental antimicrobial agents (chlorhexidine and delmopinol) on multispecies biofilms. Biofilms of 48 h and 168 h maturity were exposed to 0.2% chlorhexidine, 2% chlorhexidine and a product containing 0.2% delmopinol for 5, 10 and 20 min. 2% chlorhexidine was the most effective agent, achieving a total viable biofilm reduction ranging from 96.2% to >99.99% depending on the time of exposure and the stage of biofilm development.

Keywords

Antimicrobial susceptibility; Biofilm; Dental implant components; Disinfection.

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