2. Academic Validation
  3. Synthesis of the biotinylated anti-HIV compound BMMP and the target identification study

Synthesis of the biotinylated anti-HIV compound BMMP and the target identification study

  • Bioorg Med Chem Lett. 2016 Jan 1;26(1):43-5. doi: 10.1016/j.bmcl.2015.11.036.
Masahiro Kamo 1,  Hiroshi Tateishi 2,  Ryoko Koga 3,  Yoshinari Okamoto 4,  Masami Otsuka 5,  Mikako Fujita 6
Affiliations

Affiliations

  • 1 Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address: 141y1023@st.kumamoto-u.ac.jp.
  • 2 Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address: 155y2008@st.kumamoto-u.ac.jp.
  • 3 Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address: kk1205@kumamoto-u.ac.jp.
  • 4 Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address: okamoto@gpo.kumamoto-u.ac.jp.
  • 5 Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address: motsuka@gpo.kumamoto-u.ac.jp.
  • 6 Research Institute for Drug Discovery, School of Pharmacy, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address: mfujita@kumamoto-u.ac.jp.
PMID: 26615887 DOI: 10.1016/j.bmcl.2015.11.036
Abstract

BMMP [2-(benzothiazol-2-ylmethylthio)-4-methylpyrimidine], an inhibitor of HIV-1 replication, was linked to biotin to study the interaction with the presumed target, HIV-1 Pr55(Gag) or CA, by means of surface plasmon resonance. The synthesized Biotin-BMMP inhibited HIV-1 replication to a similar extent as BMMP alone, but did not interact with Pr55(Gag) or CA, suggesting that BMMP exerts its activity by a different mechanism.

Keywords

BMMP; Biotin; CA; HIV-1; Pr55(Gag).

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z