2. Academic Validation
  3. Steroidal Saponins from the Rhizomes of Aspidistra typica

Steroidal Saponins from the Rhizomes of Aspidistra typica

  • PLoS One. 2016 Mar 3;11(3):e0150595. doi: 10.1371/journal.pone.0150595.
Jiang-Ming Cui 1 2,  Li-Ping Kang 3,  Yang Zhao 1,  Jian-Yuan Zhao 4,  Jie Zhang 5,  Xu Pang 4,  He-Shui Yu 1,  De-Xian Jia 5,  Chao Liu 1,  Li-Yan Yu 4,  Bai-Ping Ma 1
Affiliations

Affiliations

  • 1 Beijing Institute of Radiation Medicine, Beijing, 100850, PR China.
  • 2 School of Pharmaceutical Sciences, Central South University, Changsha, 410013, China.
  • 3 State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, People's Republic of China.
  • 4 Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
  • 5 Ovation Health Science and Technology Co. Ltd., ENN Group, Langfang, 065001, China.
PMID: 26937954 DOI: 10.1371/journal.pone.0150595
Abstract

Eleven new furostanol saponins, typaspidosides B-L (1-11), one new spirostanol saponin, typaspidoside M (12), and five known spirostanol saponins, 25S-atropuroside (13), neoaspidistrin (14), (25S)-pratioside D1 (15), 25S-aspidistrin (16) and 25S-neosibiricoside (17) were isolated from the rhizomes of Aspidistra typica Baill. The structures of the new compounds were established using 1D and 2D NMR (1H-1H COSY, HMQC, HMBC and ROESY) spectroscopy, high resolution mass spectrometry, and chemical methods. The aglycones of 1-3 (unusual furostanol saponins with opened E ring type), 9 and 10 (the methoxyl substituent at C-23 position) were found, identified from natural products for the first time. Moreover, the anti-HIV activities of the isolated steroidal glycosides were assessed, and compounds 13, 14, 16 and 17 exhibited high active against HIV-1.

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