2. Academic Validation
  3. Limonoids from the roots of Trichilia sinensis and their cytotoxicities

Limonoids from the roots of Trichilia sinensis and their cytotoxicities

  • Arch Pharm Res. 2018 Dec;41(12):1170-1177. doi: 10.1007/s12272-017-0915-0.
Shou-Bai Liu 1 2,  Wen-Li Mei 1,  Hui-Qin Chen 1,  Jun Wang 1,  Zhu-Nian Wang 3,  Hao-Fu Dai 4
Affiliations

Affiliations

  • 1 Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, People's Republic of China.
  • 2 Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou, 571737, People's Republic of China.
  • 3 Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou, 571737, People's Republic of China. 13807596560@163.com.
  • 4 Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, People's Republic of China. daihaofu@itbb.org.cn.
PMID: 29170993 DOI: 10.1007/s12272-017-0915-0
Abstract

Six new compounds (1-4, 8, 10), along with six known limonoids (5-7, 9, 11, 12), were isolated from the roots of Trichilia sinensis. Their structures were elucidated on the basis of extensive spectroscopic methods including 1H NMR, 13C NMR, DEPT, HSQC, HMBC, 1H-1H COSY and ROESY experiments, as well as by comparison with the literature. All the compounds were evaluated for cytotoxicities against K562, SGC-7901 and BEL-7402 cell lines. Compounds 2, 7, 10, 11, and 12 showed weak inhibitory activity to the selected cell lines.

Keywords

Cytotoxic activities; Roots; Trichilia sinensis; Trichilin-type limonoids.

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