2. Academic Validation
  3. Alkaloids from Corydalis decumbens suppress neuronal excitability in primary cultures of mouse neocortical neurons

Alkaloids from Corydalis decumbens suppress neuronal excitability in primary cultures of mouse neocortical neurons

  • Phytochemistry. 2018 Jun:150:85-92. doi: 10.1016/j.phytochem.2018.03.006.
Qilong Huang 1,  Juan Chen 1,  Wanjin Zhang 1,  Baoping Zhou 1,  Chunlei Zhang 2,  William H Gerwick 3,  Zhengyu Cao 4
Affiliations

Affiliations

  • 1 Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Triditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, 211198, China.
  • 2 Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Triditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, 211198, China. Electronic address: zhangchunlei11@sina.com.
  • 3 Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, United States; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, United States.
  • 4 Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Triditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, 211198, China. Electronic address: zycao1999@hotmail.com.
PMID: 29571149 DOI: 10.1016/j.phytochem.2018.03.006
Abstract

Eight previously undescribed Alkaloids, named corydemine, dihydrocorydemine, corydedine, 8,13-dioxo-14-hydroxytetrahydropalmatine, egenine-α-N-oxide, egenine-β-N-oxide, 7'-O-ethylegenine-α-N-oxide, and 7'-O-ethylegenine-β-N-oxide, together with three known ones, muramine, l-tetrahydropalmatine, and (+)-egenine, were isolated from the bulbs of Corydalis decumbens. Their structures were elucidated by comprehensive spectroscopic analysis and chemical correlation. The isolated compounds were tested for their ability to modulate neuronal excitability in primary cultured neocortical neurons. Four of the compounds, corydemine, dihydrocorydemine, muramine, and l-tetrahydropalmatine, inhibited neuronal excitability with IC50 values of 3.6, 16.7, 13.5 and 14.0 μM, respectively.

Keywords

Alkaloids; Chemical correlation; Corydalis decumbens; Neuron excitability.

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