2. Academic Validation
  3. Efficient chemoenzymatic synthesis of UDP-α-6-N3-glucose

Efficient chemoenzymatic synthesis of UDP-α-6-N3-glucose

  • Bioorg Med Chem Lett. 2019 May 1;29(9):1148-1151. doi: 10.1016/j.bmcl.2019.02.002.
Jiajia Wang 1,  Dongzhe Zhang 2,  Yinhang Wen 2,  Xuefeng Cao 3,  Jing Ma 4,  Peng George Wang 5
Affiliations

Affiliations

  • 1 School of Basic Medical Sciences, Henan University Joint National Laboratory for Antibody Drug Engineering, Kaifeng, Henan 475004, People's Republic of China; Department of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University, 50 Decatur St SE, Atlanta, GA 30303, United States.
  • 2 School of Basic Medical Sciences, Henan University Joint National Laboratory for Antibody Drug Engineering, Kaifeng, Henan 475004, People's Republic of China.
  • 3 Department of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University, 50 Decatur St SE, Atlanta, GA 30303, United States.
  • 4 Institute of Chemical Biology, College of Pharmacy, Henan University, Kaifeng, People's Republic of China. Electronic address: majing.1988.ok@163.com.
  • 5 Department of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University, 50 Decatur St SE, Atlanta, GA 30303, United States. Electronic address: pwang11@gsu.edu.
PMID: 30826291 DOI: 10.1016/j.bmcl.2019.02.002
Abstract

A novel chemo-enzymatic synthetic method for UDP-α-6-N3-glucose was developed by combining the versatility of chemical synthesis and natural enzyme stereo-selectivity of Bifidobacterium longum (BLUSP). This flexible and efficient platform expanded the substrate scope for UDP-sugars on an improved scale, particularly for UDP-sugar substrates containing bioorthogonal functional groups.

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