2. Academic Validation
  3. Phenolic constituents with neuroprotective activities from Hypericum wightianum

Phenolic constituents with neuroprotective activities from Hypericum wightianum

  • Phytochemistry. 2019 Sep:165:112049. doi: 10.1016/j.phytochem.2019.112049.
Ling Yang 1,  Zi-Ming Wang 2,  Yun Wang 2,  Rong-Sheng Li 2,  Fei Wang 3,  Kou Wang 4
Affiliations

Affiliations

  • 1 School of Pharmacy and Yunnan Key Laboratory of Natural Medicine Pharmacology, Kunming Medical University, Kunming, 650500, PR China; Tongren Polytechnic College, Guizhou, 554300, PR China.
  • 2 School of Pharmacy and Yunnan Key Laboratory of Natural Medicine Pharmacology, Kunming Medical University, Kunming, 650500, PR China.
  • 3 BioBioPha Co., Ltd., Kunming 650201, PR China. Electronic address: f.wang@mail.biobiopha.com.
  • 4 School of Pharmacy and Yunnan Key Laboratory of Natural Medicine Pharmacology, Kunming Medical University, Kunming, 650500, PR China. Electronic address: koko_yaya@163.com.
PMID: 31229788 DOI: 10.1016/j.phytochem.2019.112049
Abstract

Five undescribed phenolic compounds, inclusing a depsidone derivative, hyperwightin A, a flavone derivative, hyperwightin B, and three benzophenone glycosides, hyperwightins C-E, along with four known ones were isolated from the 95% EtOH extract of the whole Plants of Hypericum wightianum. Structures of the obtained compounds were elucidated by spectroscopic analyses. The protective effects of the isolates against corticosterone-induced PC12 cell injury were assessed. Hyperwightin E, petiolin G and hyperxanthone exhibited noticeable neuroprotection at 10 μM.

Keywords

Benzophenone glycosides; Depsidone; Flavone derivative; Hypericaceae; Hypericum wightianum wall. ex wight et Arn.; Neuroprotective activity.

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