2. Academic Validation
  3. Propagermanium Induces NK Cell Maturation and Tends to Prolong Overall Survival of Patients With Refractory Cancer

Propagermanium Induces NK Cell Maturation and Tends to Prolong Overall Survival of Patients With Refractory Cancer

  • Anticancer Res. 2019 Sep;39(9):4687-4698. doi: 10.21873/anticanres.13651.
Shojiro Kikuchi 1,  Kazuma Noguchi 2,  Keiko Wakai 3,  Yoko Hamazaki 4,  Katsuyuki Tozawa 5,  Takahito Jomori 6,  Mitsuru Sasako 7,  Hiroto Miwa 5
Affiliations

Affiliations

  • 1 Institute for Advanced Medical Science, Hyogo College of Medicine, Nishinomiya, Japan skikuchi@hyo-med.ac.jp.
  • 2 Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
  • 3 Institute for Advanced Medical Science, Hyogo College of Medicine, Nishinomiya, Japan.
  • 4 Department of Life Science Frontiers, CiRA, Kyoto University, Kyoto, Japan.
  • 5 Department of Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
  • 6 Sanwa Kagaku Kenkyusho Co., Ltd., Nagoya, Japan.
  • 7 Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
PMID: 31519568 DOI: 10.21873/anticanres.13651
Abstract

Background/aim: Propagermanium (PG) inhibits the CCL2/CCR2 axis, and has been shown to function as an immune modulator. This study investigated its anti-tumor mechanism in patients with refractory cancers.

Materials and methods: Five healthy volunteers and 23 patients with refractory oral (n=8) or gastric (n=15) Cancer received PG (30 mg/day). We performed flow cytometry (FCM) of peripheral blood mononuclear cells and in vitro killing assays.

Results: FCM revealed that CD16+/CD56Dim NK cells (i.e., mature, cytolytic subset) increased, and the Apoptosis induction rate of Cancer cells increased after PG administration. Among gastric Cancer patients, median OS was 172.0 days. Two patients showed complete remission of lung or liver metastasis. Survival of patients with oral Cancer also tended to be prolonged.

Conclusion: PG induces NK cell maturation, and may potentiate anti-tumor activity.

Keywords

NK cells; Propagermanium; gastric cancer; maturation; oral cancer.

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