2. Academic Validation
  3. Bioactive bisbenzylisoquinoline alkaloids from the roots of Stephania tetrandra

Bioactive bisbenzylisoquinoline alkaloids from the roots of Stephania tetrandra

  • Bioorg Chem. 2020 May:98:103697. doi: 10.1016/j.bioorg.2020.103697.
Renzhong Wang 1,  Yanfei Liu 1,  Guoru Shi 1,  Jie Zhou 1,  Jiayuan Li 1,  Li Li 1,  Jiqiao Yuan 1,  Xuyu Li 1,  Dequan Yu 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
  • 2 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address: dqyu@imm.ac.cn.
PMID: 32182518 DOI: 10.1016/j.bioorg.2020.103697
Abstract

Ten new Bisbenzylisoquinoline Alkaloids (1-10) and eight known analogues (11-18) were obtained from the roots of Stephania tetrandra. The structures of these compounds were determined by spectroscopic methods, single-crystal X-ray diffraction, electronic circular dichroism analyses, and chemical method. Compounds 1, 15, and 16 showed the better anti-inflammatory activities with IC50 values of 15.26 ± 2.99, 6.12 ± 0.25, and 5.92 ± 1.89 μM, respectively. Compound 18 possessed cytotoxic activities against MCF-7, HCT-116, and HepG2 cell lines with IC50 values of 2.81 ± 0.06, 3.66 ± 0.26, and 2.85 ± 0.15 μM, respectively.

Keywords

Anti-inflammatory activities; Bisbenzylisoquinoline alkaloids; Cytotoxicity; Menispermaceae; Stephania tetrandra.

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