2. Academic Validation
  3. Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera

Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera

  • Bioorg Chem. 2020 Nov:104:104298. doi: 10.1016/j.bioorg.2020.104298.
Milan Malaník 1,  Jakub Treml 2,  Veronika Leláková 2,  Daniela Nykodýmová 2,  Michal Oravec 3,  Jaromír Marek 4,  Karel Šmejkal 5
Affiliations

Affiliations

  • 1 Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, Palackého třída 1946/1, 61200 Brno, Czech Republic. Electronic address: milan.malanik@seznam.cz.
  • 2 Department of Molecular Pharmacy, Faculty of Pharmacy, Masaryk University, Palackého třída 1946/1, 61200 Brno, Czech Republic.
  • 3 Global Change Research Institute of the Czech Academy of Sciences, Bělidla 986/4a, 60300 Brno, Czech Republic.
  • 4 X-ray Diffraction and Bio-SAXS Core Facility, Central European Institute of Technology, Masaryk University, Kamenice 5, 62500 Brno, Czech Republic.
  • 5 Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, Palackého třída 1946/1, 61200 Brno, Czech Republic. Electronic address: karel.mejkal@post.cz.
PMID: 33011537 DOI: 10.1016/j.bioorg.2020.104298
Abstract

Extensive phytochemical analysis of the CHCl3-soluble part of an ethanolic extract of branches and twigs of Broussonetia papyrifera led to the isolation of fourteen compounds, including a novel 5,11-dioxabenzo[b]fluoren-10-one derivative named broussofluorenone C (12). The isolated compounds 1-14 were characterized based on their NMR and HRMS data, and examined for their anti-inflammatory activities in LPS-stimulated THP-1 cells as well as for their cellular antioxidant effects. Compounds 7-10 and 12 showed inhibitory effects on NF-κB/AP-1 activation and compounds 7-9 were subsequently confirmed to suppress the secretion of both IL-1β and TNF-α in LPS-stimulated THP-1 cells more significantly than the prednisone used as a positive control. In the CAA assay, compound 10 exhibited the greatest antioxidant effect, greater than that of the quercetin used as a positive control. The results show possible beneficial effects and utilization of B. papyrifera wood in the treatment of inflammatory diseases as well as oxidative stress.

Keywords

Anti-inflammatory; Antioxidant; Broussonetia papyrifera; NF-κB.

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