2. Academic Validation
  3. Nitrilase: a promising biocatalyst in industrial applications for green chemistry

Nitrilase: a promising biocatalyst in industrial applications for green chemistry

  • Crit Rev Biotechnol. 2021 Feb;41(1):72-93. doi: 10.1080/07388551.2020.1827367.
Ji-Dong Shen 1 2,  Xue Cai 1 2,  Zhi-Qiang Liu 1 2,  Yu-Guo Zheng 1 2
Affiliations

Affiliations

  • 1 Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, P. R. China.
  • 2 Engineering Research Center of Bioconversion and Biopurification of Ministry of Education, Zhejiang University of Technology, Hangzhou, P.R. China.
PMID: 33045860 DOI: 10.1080/07388551.2020.1827367
Abstract

Nitrilases are widely distributed in nature and are able to hydrolyze nitriles into their corresponding carboxylic acids and ammonia. In industry, nitrilases have been used as green biocatalysts for the production of high value-added products. To date, biocatalysts are considered to be important alternatives to chemical catalysts due to increasing environmental problems and resource scarcity. This review provides an overview of recent advances of nitrilases in aspects of distribution, enzyme screening, molecular structure and catalytic mechanism, protein engineering, and their potential applications in industry.

Keywords

Nitrilase; biocatalyst; biotechnological applications; biotransformation; carboxylic acid synthesis; structure–activity relationship.

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