2. Academic Validation
  3. Plant Volatile, Phenylacetaldehyde Targets Breast Cancer Stem Cell by Induction of ROS and Regulation of Stat3 Signal

Plant Volatile, Phenylacetaldehyde Targets Breast Cancer Stem Cell by Induction of ROS and Regulation of Stat3 Signal

  • Antioxidants (Basel). 2020 Nov 13;9(11):1119. doi: 10.3390/antiox9111119.
Hack Sun Choi 1,  Su-Lim Kim 2 3 4 5,  Ji-Hyang Kim 2 3 4 5,  Yu-Chan Ko 2,  Dong-Sun Lee 1 2 3 4 5
Affiliations

Affiliations

  • 1 Subtropical/Tropical Organism Gene Bank, Jeju National University, Jeju 63243, Korea.
  • 2 Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Korea.
  • 3 School of Biomaterials Science and Technology, College of Applied Life Science, Jeju National University, Jeju 63243, Korea.
  • 4 Faculty of Biotechnology, College of Applied Life Sciences, Jeju National University, SARI, Jeju 63243, Korea.
  • 5 Practical Translational Research Center, Jeju National University, Jeju 63243, Korea.
PMID: 33202749 DOI: 10.3390/antiox9111119
Abstract

Cancer Stem Cells (CSCs) are undifferentiated cells that give rise to tumor and resistance to chemotherapy. This study reports that phenylacetaldehyde (PAA), a flower flavor, inhibits formation on breast CSCs. PAA showed anti-proliferation and increased Apoptosis of breast Cancer. PAA also reduced tumor growth in an in vivo mice model. PAA reduced the CD44+/CD24- and ALDH1-expressing cells, mammosphere formation, and CSC marker genes. PAA preferentially induced Reactive Oxygen Species (ROS) production and combined treatment with PAA and N-acetyl cysteine (NAC) decreased inhibition of mammosphere formation. PAA reduced phosphorylation of nuclear STAT3. PAA inhibited STAT3 signaling through de-phosphorylation of STAT3 and reduced secretory IL-6. Our results suggest that the PAA-induced ROS deregulated STAT3/IL-6 pathway and PAA may be a potential agent targeting breast Cancer and CSCs.

Keywords

ROS; Stat3; breast cancer; cancer stem cells (CSCs); phenylacetaldehyde (PAA).

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  • HY-W102525
    单萜类化合物
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