2. Academic Validation
  3. Sch 36605, a novel anti-inflammatory compound. Taxonomy, fermentation, isolation and biological properties

Sch 36605, a novel anti-inflammatory compound. Taxonomy, fermentation, isolation and biological properties

  • J Antibiot (Tokyo). 1988 Jan;41(1):20-4. doi: 10.7164/antibiotics.41.20.
V Gullo 1,  M Conover,  R Cooper,  C Federbush,  A C Horan,  T Kung,  J Marquez,  M Patel,  A Watnick
Affiliations

Affiliation

  • 1 Pharmaceutical Research Division, Schering Plough Corporation, Bloomfield, New Jersey 07003.
PMID: 3346189 DOI: 10.7164/antibiotics.41.20
Abstract

A novel anti-inflammatory compound, Sch 36605, belonging to the blasticidin family of nucleoside compounds was isolated from the fermentation filtrate of a Streptomyces sp. Sch 36605, as well as blasticidin S, demonstrated anti-inflammatory activity in the reverse passive Arthus reaction and the Adjuvant arthritic rat at doses ranging between 1-10 mg/kg and 0.3-6.0 mg/kg, respectively. A minor component, Sch 366606, co-produced in the in the fermentation was isolated and identified as a known compound in the blasticidin family of compounds.

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