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  3. Chemical constituents from Lycopodiella cernua and their anti-inflammatory and cytotoxic activities

Chemical constituents from Lycopodiella cernua and their anti-inflammatory and cytotoxic activities

  • Nat Prod Res. 2022 Aug;36(16):4045-4051. doi: 10.1080/14786419.2021.1958807.
Vu Huong Giang 1,  Le Thi Thuy 2,  Pham Thi Cham 1,  Le Ba Vinh 1 3,  Ninh Khac Ban 1,  Tran My Linh 1,  Nguyen Chi Mai 1,  Pham Thi Hoe 1,  Tran Thu Huong 2,  Nguyen Hai Dang 4,  Hyuncheol Oh 3,  Tran Hong Quang 1
Affiliations

Affiliations

  • 1 Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
  • 2 School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, Vietnam.
  • 3 College of Pharmacy, Wonkwang University, Iksan, Republic of Korea.
  • 4 University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
PMID: 34498971 DOI: 10.1080/14786419.2021.1958807
Abstract

Phytochemical investigation of the whole Plants of Lycopodiella cernua resulted in the isolation and identification of three new compounds (1-3), namely lycocernuaside E (1), lycernuic ketone F (2), and lycernuic B (3) and 12 known ones (4-15). Their chemical structures were established based on 1 D/2D NMR spectroscopic and HR-ESI-MS data analyses. Compounds 5, 12, and 13 displayed NO inhibitory effects in LPS-stimulated BV2 cells, with IC50 values of 21.2 ± 1.1, 28.5 ± 1.4, and 21.9 ± 1.1 µM, respectively. In addition, cytotoxic activity of the isolated compounds against MCF7 (breast carcinoma), HepG2 (hepatocarcinoma), and SK-Mel2 (melanoma) Cancer cell lines were also reported.

Keywords

Lycopodiella cernua; neolignan glycoside; serratene-type triterpenoid.

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