1. Academic Validation
  2. Two new chromones and a new coumarin from the fruit of Cnidium monnieri (L.) Cusson

Two new chromones and a new coumarin from the fruit of Cnidium monnieri (L.) Cusson

  • Nat Prod Res. 2023 Jan;37(1):47-55. doi: 10.1080/14786419.2021.1948042.
Hui-Chi Huang 1 2 Chun-Hsiang Lin 3 Ching-Chuan Kuo 4 Ming-Der Wu 5 Ming-Jen Cheng 5 Jih-Jung Chen 6 Che-Yi Chao 7 Guan-Jhong Huang 1 Yueh-Hsiung Kuo 1 8 9
Affiliations

Affiliations

  • 1 Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan.
  • 2 Master Program for Food and Drug Safety, China Medical University, Taichung, Taiwan.
  • 3 Department of Chemistry, National Taiwan University, Taipei, Taiwan.
  • 4 Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan.
  • 5 Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, Taiwan.
  • 6 Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan.
  • 7 Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.
  • 8 Department of Biotechnology, Asia University, Taichung, Taiwan.
  • 9 Chinese Medicine Research Center, China Medical University, Taichung, Taiwan.
Abstract

Two new chromones named cnidimol G (1) and cnidimol H (2), one new coumarin, 7-methoxy-8-(3-methoxy-3-methyl-2-oxobutyl)coumarin (3), and twenty known compounds were isolated from MeOH extract of the fruit of Cnidium monnieri (L.) Cusson. The structures of compounds were elucidated by extensive spectroscopic analyses including 1 D and 2 D NMR, HRESIMS, IR and UV. Anti-inflammatory activity of the selected isolated compounds were evaluated. Compounds 1 and 8 exhibited inhibitory activities against nitric oxide production.

Keywords

Cnidium monnieri (L.) Cusson; anti-inflammatory activity; chromones; coumarin.

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