2. Academic Validation
  3. Studies on the affinity and selectivity of tiquizium bromide (HSR-902), a novel spasmolytic agent, for muscarinic receptors

Studies on the affinity and selectivity of tiquizium bromide (HSR-902), a novel spasmolytic agent, for muscarinic receptors

  • Jpn J Pharmacol. 1987 Jun;44(2):222-4. doi: 10.1254/jjp.44.222.
M Oshita 1,  T Ohashi,  K Morikawa,  H Kato,  Y Ito,  I Muramatsu
Affiliations

Affiliation

  • 1 Research Laboratories, Hokuriku Seiyaku Co., Ltd., Fukui, Japan.
PMID: 3656779 DOI: 10.1254/jjp.44.222
Abstract

The affinity and selectivity of a novel spasmolytic agent, tiquizium bromide (HSR-902), for muscarinic receptors were studied by the radioligand binding technique using 3H-quinuclidinyl benzilate. The parameters (Ki, nH) of HSR-902 obtained from competition experiments in cerebral cortex and heart muscarinic receptors showed that HSR-902 was an atropine-type, nonselective muscarinic antagonist. The affinity of HSR-902 toward the stomach and ileal muscarinic receptors was about 3-4 times more potent than atropine.

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