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  2. Harnessing the dual antimicrobial mode of action with a lipophilic Mn(II) complex using the principle of the Irving-Williams Series to completely eradicate Staphylococcus aurous

Harnessing the dual antimicrobial mode of action with a lipophilic Mn(II) complex using the principle of the Irving-Williams Series to completely eradicate Staphylococcus aurous

  • Dalton Trans. 2023 Sep 13;52(35):12203-12207. doi: 10.1039/d3dt01904g.
Khalil Mudarmah 1 2 Bijaya Bagale 1 Guanyu Chen 1 Jeanette A Krause 3 Jeffrey D Mighion 1 Songping D Huang 1
Affiliations

Affiliations

  • 1 Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA. shuang1@kent.edu.
  • 2 Department of Chemistry, Jazan University, Jazan, 45142, Saudi Arabia.
  • 3 Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221-0172, USA.
Abstract

The judicious selection of 5,7-dibromo-2-methy-8-quinolinol (BQ) as a Mn(II) ionophore results in the synthesis of Mn(BQ)2(DMSO)2·DMSO (1), a potent metalloantibiotic with a dual antimicrobial mode of action against four different strains of Staphylococcus aurous (SA) bacteria (MIC = 0.625 μg mL-1). Additionally, 1 can overcome ciprofloxacin-resistance in methicillin-resistant SA bacteria.

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