2. Academic Validation
  3. BCMA CAR-T cells in multiple myeloma-ready for take-off?

BCMA CAR-T cells in multiple myeloma-ready for take-off?

  • Leuk Lymphoma. 2024 Feb;65(2):143-157. doi: 10.1080/10428194.2023.2276676.
Lukas Scheller 1 2,  Erius Tebuka 3 4,  Peter Fabian Rambau 3,  Hermann Einsele 1,  Michael Hudecek 1,  Sabrina Rebecca Prommersberger 1,  Sophia Danhof 1 5
Affiliations

Affiliations

  • 1 Medizinische Klinik und Poliklinik II und Lehrstuhl für zelluläre Immuntherapie, Medizinische Klinik II, Universitätsklinikum Würzburg, Würzburg, Germany.
  • 2 Interdisziplinäres Zentrum für Klinische Forschung (IZKF), Universitätsklinikum Würzburg, Würzburg, Germany.
  • 3 Department of Pathology, Catholic University of Health and Allied Sciences (CUHAS), Mwanza, Tanzania.
  • 4 Else-Kröner-Center Würzburg-Mwanza, Catholic University of Health and Allied Sciences (CUHAS), Mwanza, Tanzania.
  • 5 Mildred Scheel Early Career Center, Universitätsklinikum Würzburg, Würzburg, Germany.
PMID: 37997705 DOI: 10.1080/10428194.2023.2276676
Abstract

Although the approval of new drugs has improved the clinical outcome of multiple myeloma (MM), it was widely regarded as incurable over the past decades. However, recent advancements in groundbreaking immunotherapies, such as chimeric antigen receptor T cells (CAR-T), have yielded remarkable results in heavily pretreated relapse/refractory patients, instilling hope for a potential cure. CAR-T are genetically modified cells armed with a novel receptor to specifically recognize and kill tumor cells. Among the potential targets for MM, the B-cell maturation antigen (BCMA) stands out since it is highly and almost exclusively expressed on plasma cells. Here, we review the currently approved BCMA-directed CAR-T products and ongoing clinical trials in MM. Furthermore, we explore innovative approaches to enhance BCMA-directed CAR-T and overcome potential reasons for treatment failure. Additionally, we explore the side effects associated with these novel therapies and shed light on accessibility of CAR-T therapy around the world.

Keywords

BCMA; CAR-T; chimeric antigen receptor T cell; clinical trials; multiple myeloma.

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