2. Academic Validation
  3. Isolation, characterization and anti-inflammatory effect of alkaloids from the roots of Stemona tuberosa Lour

Isolation, characterization and anti-inflammatory effect of alkaloids from the roots of Stemona tuberosa Lour

  • Phytochemistry. 2024 Apr:220:114013. doi: 10.1016/j.phytochem.2024.114013.
Na Zhang 1,  Yang Xu 1,  Xinyi Yue 1,  Liangliang Xiong 1,  Hua Li 2,  Lixia Chen 3
Affiliations

Affiliations

  • 1 Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.
  • 2 Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China; Institute of Structural Pharmacology & TCM Chemical Biology, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China. Electronic address: 2022041@fjtcm.edu.cn.
  • 3 Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address: syzyclx@163.com.
PMID: 38331134 DOI: 10.1016/j.phytochem.2024.114013
Abstract

Six undescribed Alkaloids, neotuberostemonol C (1), dehydrostenines C-D (2-3), tuberostemonines Q-R (10-11), and (6R,8R,8aR)-8-hydroxy-6-methyl-hexahydroindolizin-5-one (32), along with twenty-six known analogues were isolated from the dried roots of Stemona tuberosa Lour. The structures and absolute stereochemistry of these compounds were delineated by extensive spectroscopy (1D NMR, 2D NMR, HRESIMS), quantum chemical calculations of the electronic circular dichroism spectra, and pyridine-induced solvent shifts. Tuberostemonines Q-R (10-11) represent tuberostemonine skeleton Alkaloids possessing an α-methyl-γ-butyrolactone moiety attached to C-3. In addition, all these isolated compounds were assayed for their inhibitory activity against LPS-induced NO production in RAW264.7 cells using Griess assay.

Keywords

Alkaloids; Anti-inflammatory activity; Stemona tuberosa Lour.; Stemonaceae; Stenine-type alkaloids.

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