2. Academic Validation
  3. Cu(II)/PTABS-Promoted, Chemoselective Amination of HaloPyrimidines

Cu(II)/PTABS-Promoted, Chemoselective Amination of HaloPyrimidines

  • J Org Chem. 2024 Jul 5;89(13):9243-9254. doi: 10.1021/acs.joc.4c00171.
Vikram Phulwale 1,  Harshita Shet 1,  Krishna Chaitanya Gunturu 2,  Smruti Rekha Rout 3,  Rambabu Dandela 3,  Suyog Adhav 4,  Anant R Kapdi 1
Affiliations

Affiliations

  • 1 Department of Chemistry, Institute of Chemical Technology, Nathalal Parekh Road, Matunga, Mumbai 400019, India.
  • 2 School of Chemical Sciences, SRTM University, Nanded 431606, India.
  • 3 Department of Industrial and Engineering Chemistry, Institute of Chemical Technology-Indian Oil Odisha Campus , Samantpuri, Bhubaneswar, Odisha 751013, India.
  • 4 BASF Chemicals India Pvt. Ltd., Plot No 12, Thane Belapur Road, Navi Mumbai 400705, India.
PMID: 38878304 DOI: 10.1021/acs.joc.4c00171
Abstract

Chemoselective amination is a highly desired synthetic methodology, given its importance as a possible strategy to synthesize various drug molecules and agrochemicals. We, herein, disclose a highly chemoselective Cu(II)-PTABS-promoted amination of pyrimidine structural feature containing different halogen atoms.

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