2. Academic Validation
  3. Phenanthrenes from Juncus articulatus with Antibacterial and Biofilm Formation Inhibitory Activity

Phenanthrenes from Juncus articulatus with Antibacterial and Biofilm Formation Inhibitory Activity

  • J Nat Prod. 2024 Aug 23;87(8):2068-2080. doi: 10.1021/acs.jnatprod.4c00577.
Anita Barta 1 2,  Agostina Salusso 3,  Norbert Kúsz 1,  Róbert Berkecz 4,  Jan Schlauer 5,  Dragica Purger 6,  Judit Hohmann 1 2,  Maria Cecilia Carpinella 3,  Andrea Vasas 1 2
Affiliations

Affiliations

  • 1 Institute of Pharmacognosy, University of Szeged, Szeged 6720, Hungary.
  • 2 HUN-REN-USZ Biologically Active Natural Products Research Group, University of Szeged, Szeged 6720, Hungary.
  • 3 Fine Chemical and Natural Products Laboratory, CIDIE CONICET-UCC, Universidad Católica de Córdoba, Córdoba X5016DHK, Argentina.
  • 4 Institute of Pharmaceutical Analysis, University of Szeged, Szeged 6720, Hungary.
  • 5 The Center for Plant Molecular Biology, University of Tubingen, Tubingen 72076, Germany.
  • 6 Department of Pharmacognosy, University of Pécs, Pécs 7624, Hungary.
PMID: 39121346 DOI: 10.1021/acs.jnatprod.4c00577
Abstract

Continuing our search for bioactive compounds in species from the Juncaceae family, Juncus articulatus was investigated. Ten previously undescribed phenanthrenes─articulins A-J (1-10)─and ten known compounds─juncuenin B, dehydrojuncuenin B, juncatrin B, ensifolins E, F, H, I, K, juncuenin D, and luzulin A (11-20)─along with Other compounds, have been isolated and identified. The isolated compounds were evaluated for Antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, methicillin-susceptible Staphylococcus aureus (MSSA), and methicillin-resistant Staphylococcus aureus (MRSA). Compounds 12 and 14 exhibited the most potent activity against planktonic and sessile MSSA and MRSA with minimum inhibitory concentration (MIC) values of 15.1 μM (12 for both Bacterial strains) and 15.3 μM (14 for both Bacterial strains). Compounds 15, 17, and 18 also exhibited activity against both strains, although to a lower extent, with MIC values ranging from 30.0 to 56.8 μM. The inhibition of biofilm formation of these compounds was observed at 15.1-114.3 μM. This study elucidates the phenanthrene composition of J. articulatus and the Antibacterial effect of these compounds.

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