A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite-CerS6-ceramide axis

Affiliations

• 1 Department of Immunology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Third Hospital, Peking University, Beijing, China.
• 2 NHC Key Laboratory of Medical Immunology, Peking University, Beijing, China.
• 3 Department of Physiology and Pathophysiology, Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
• 4 Center of Basic Medical Research, Institute of Medical Innovation and Research, Beijing Key Laboratory for Interdisciplinary Research in Gastrointestinal Oncology, Peking University Third Hospital, Beijing, China.
• 5 Department of Hepatology, Qilu Hospital of Shandong University, Jinan, China.
• 6 Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
• 7 Department of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, China.
• 8 Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
• 9 Department of Colorectal Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
• 10 MAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
• 11 Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China.
• 12 Translational Medicine Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
• 13 State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
• 14 Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Institute of Advanced Clinical Medicine, Peking University, Beijing, China.
• 15 National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.
• 16 Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China.
• # Contributed equally.