NSD2 targeting reverses plasticity and drug resistance in prostate cancer

Affiliations

• 1 Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
• 2 Department of Systems Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
• 3 Department of Genetics and Development, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
• 4 Department of Urology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
• 5 Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
• 6 Center for Data Science and Artificial Intelligence, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
• 7 Center for Therapeutics Discovery, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
• 8 Cancer Genome and Epigenetics Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
• 9 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• 10 Marine College, Shandong University, Weihai, China.
• 11 Organic Synthesis Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• 12 Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA.
• 13 Department of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
• 14 Department of Biology, Stanford University, Stanford, CA, USA.
• 15 Department of Molecular Pharmacology and Therapeutics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
• 16 Arvinas, New Haven, CT, USA.
• 17 Division of Clinical Studies, The Institute of Cancer Research, London, UK.
• 18 Haematopathology Division, IEO European Institute of Oncology, Milan, Italy.
• 19 Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
• 20 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• 21 Department of Biomedical Research, Bern Center for Precision Medicine, University of Bern, Bern, Switzerland.
• 22 Nuffield Department of Surgical Sciences, Lincoln College, University of Oxford, Oxford, UK.
• 23 Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• 24 Department of Biomedical Informatics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
• 25 Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
• 26 Chan Zuckerberg Biohub, New York, NY, USA.
• 27 Department of Genetics and Development, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. cl3684@cumc.columbia.edu.
• 28 Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. cl3684@cumc.columbia.edu.
• 29 Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. mshen@columbia.edu.
• 30 Department of Systems Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. mshen@columbia.edu.
• 31 Department of Genetics and Development, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. mshen@columbia.edu.
• 32 Department of Urology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. mshen@columbia.edu.
• 33 Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. mshen@columbia.edu.
• # Contributed equally.