Bridging the gap with amide linkers: rational design, synthesis, and multi-target evaluation of sulfonamide/acetamide-NSAID hybrids as dual COX-2/5-LOX inhibitors

Affiliations

• 1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sinai University, Ismailia, Egypt.
• 2 Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.
• 3 Department of Chemistry, Faculty of Science (Boys), Al-Azhar University, Nasr City, Egypt.
• 4 Polymer Institute of the Slovak Academy of Sciences PSAS, Bratislava, Slovak Republic.
• 5 Chemistry Department, Faculty of Science, Galala University, Suez, Egypt.
• 6 Small Animal Clinical Sciences Department, College of Veterinary Medicine, University of Florida, Gainesville, USA.
• 7 General Division for Biological Control and Research, Egyptian Drug Authority, Cairo, Egypt.
• 8 Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.
• 9 Pharmacology and Toxicology Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
• 10 Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.
• 11 Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.