1. MCH-1 antagonist 2

MCH-1 antagonist 2 (l-BROMO-2,4-DIFLUORO-5-NITROBEN-ZENE) 是一种选择性靶向黑色素聚集激素 MCH1 受体的 4-芳基哌啶类化合物。MCH-1 antagonist 2 可用于抑郁症、焦虑症、肥胖症、急迫性尿失禁、尿失禁、重度抑郁症、双相情感障碍、广场恐怖症、特定恐怖症、社交恐怖症、强迫症、创伤后应激障碍、急性应激障碍、尿频、尿急、夜尿症、遗尿症、贪食症、神经性贪食症、神经性厌食症、重度抑郁障碍、心境恶劣障碍、双相Ⅰ型和Ⅱ型障碍、分裂情感性障碍、伴抑郁心境的认知障碍、人格障碍、失眠症、嗜睡症、发作性睡病、昼夜节律睡眠障碍、梦魇障碍、睡惊症、睡行症、惊恐障碍、社交焦虑障碍、广泛性焦虑障碍以及膀胱过度活动症的研究。

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MCH-1 antagonist 2

MCH-1 antagonist 2 Chemical Structure

CAS No. : 345-24-4

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  • 生物活性

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生物活性

MCH-1 antagonist 2 (l-BROMO-2,4-DIFLUORO-5-NITROBEN-ZENE) is a melanin concentrating hormone-1 (MCH1) receptor-selective 4-aryl piperidine. MCH-1 antagonist 2 can be used for the research of depression, anxiety, obesity, urge incontinence, urinary incontinence, major depression, bipolar disorder, agoraphobia, specific phobia, social phobia, obsessive-compulsive disorder, post-traumatic stress disorder, acute stress disorder, urinary frequency, urinary urgency, nocturia, enuresis, bulimia, bulimia nervosa, anorexia nervosa, major depressive disorder, dysthymic disorder, bipolar 1 and 2 disorders, schizoaffective disorder, cognitive disorders with depressed mood, personality disorders, insomnia, hypersomnia, narcolepsy, circadian rhythm sleep disorder, nightmare disorder, sleep terror disorder, sleepwalking disorder, panic disorder, social anxiety disorder, generalized anxiety disorder, overactive bladder[1].

分子量

237.99

Formula

C6H2BrF2NO2

CAS 号
性状

<19°C 固体,>19°C 液体

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
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参考文献

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MCH-1 antagonist 2
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