2. NF-κB
  3. NF-κB
  4. mcIRBP-9

mcIRBP-9 是一种具有口服生物利用度的 NF-κB 抑制剂。mcIRBP-9 可降低肾脏组织中 TNF-α、IL-1β 和 TGF-β1 的水平，并减少 LPS 诱导的 IL-1β 生成。mcIRBP-9 可用于糖尿病肾病及 2 型糖尿病的相关研究。

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Custom Peptide Synthesis

mcIRBP-9

mcIRBP-9 Chemical Structure

CAS No. : 1489241-80-6

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mcIRBP-9 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

mcIRBP-9 is an orally bioavailable NF-κB inhibitor. mcIRBP-9 reduces the levels of TNF-α, IL-1β and TGF-β1 in renal tissues, and decreases LPS-induced IL-1β production. mcIRBP-9 can be used in research related to diabetic nephropathy and type 2 diabetes mellitus[1].

体内研究
(In Vivo)

mcIRBP-9 (1-10 μmol kg−1；灌胃；每日 1 次或单次给药；连续 12 周或短期给药) 可呈剂量依赖性改善葡萄糖清除能力，降低长期血糖及 HbA1c 水平，将存活率提升至 100%，并通过抗炎及肾保护作用改善 db/db 小鼠的糖尿病肾病[1]。
mcIRBP-9 (1 μmol kg−1；灌胃；LPS 刺激后单次给药) 可在 NF-κB 转基因小鼠中抑制 LPS 诱导的肾 NF-κB 活性及系统性 IL-1β 产生，展现出与肾病相关的抗炎活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NF-κB transgenic (male, 6-week-old)[1]
Dosage: 1 μmol kg-1
Administration: p.o.; single dose given after LPS challenge
Result: Reduced serum IL-1β levels by 69.28 % compared to LPS-only controls.
Suppressed LPS-induced renal NF-κB-dependent luminescent intensities by 61.78 % compared to LPS-only controls.
分子量

923.11

Formula

C42H74N12O11
CAS 号
Sequence

Ile-Val-Ala-Arg-Pro-Pro-Thr-Ile-Gly
Sequence Shortening

IVARPPTIG
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

mcIRBP-9 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mcIRBP-91489241-80-6mcIRBP9mcIRBP 9NF-κBNuclear factor-κBNuclear factor-kappaBHbA1crenal cellsLPSdiabetic nephropathyTNF-αtype 2 diabetesTGF-β1db/db miceIL-1βInhibitorinhibitorinhibit

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