MCPA sodium 

MCPA sodium is an orally active phenoxyacetic acid herbicide. MCPA sodium interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA sodium increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA sodium can be used to control broadleaf weeds^{[1][2][3][4][5]}.

MCPA (50 μM) sodium 被 Caco-2 细胞吸收，主要通过与苯甲酸共用的单羧酸转运蛋白，部分通过 L-乳酸吸收^[1]。
MCPA (20-120 μM；4 周) sodium 可抑制非绿色马铃薯块茎愈伤组织的生长，破坏膜完整性，降低能量电荷，并影响氧化还原状态和抗氧化酶活性^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MCPA (200 mg/kg/天；口服；2 周) sodium 可提高雄性大鼠肝细胞色素 P-450 水平以及苯胺羟化酶和 7-乙氧基香豆素 O-脱乙基酶的活性^[4]。
MCPA (¹⁴C-MCPA；5-100 mg/kg；口服；单剂量或多剂量) sodium 在大鼠体内被快速吸收，主要通过尿液排泄，代谢为 HMCPA 和甘氨酸结合物的数量有限^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

222.60

C₉H₈ClNaO₃

3653-48-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kimura O, et al. Uptake of 4-chloro-2-methylphenoxyacetic acid (MCPA) from the apical membrane of Caco-2 cells by the monocarboxylic acid transporter. Toxicol Appl Pharmacol. 2008 Mar 15;227(3):325-30.  [Content Brief]

  [2]. Peixoto F P, et al. Toxicity of MCPA on non-green potato tuber calli. Acta Physiologiae Plantarum, 2009, 31(1): 103-109.

  [3]. Gao Y F, et al. The influence of chlorophenoxy herbicides MCPA on creeping bentgrass physiological index. Advanced Materials Research, 2012, 356: 2763-2766.

  [4]. Inomata N, et al. Effects of MCPA and other phenoxyacid compounds on hepatic xenobiotic metabolism in rats. Tohoku J Exp Med. 1991 Nov;165(3):171-82.  [Content Brief]

  [5]. van Ravenzwaay B, et al. Absorption, distribution, metabolism and excretion of 4-chloro-2-methylphenoxyacetic acid (MCPA) in rats. Food Chem Toxicol. 2004 Jan;42(1):115-25.  [Content Brief]