2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. MCULE-3064932370

MCULE-3064932370 是一种共价变构 SUMO E1 (Aos1 和 Uba2 的异源二聚体) 抑制剂，其 IC50 值范围为 16.66 μM 至 2.96 μM。MCULE-3064932370 可抑制 Uba2 的 SUMO 化修饰。MCULE-3064932370 对乳腺癌具有抗癌活性。

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MCULE-3064932370

MCULE-3064932370 Chemical Structure

CAS No. : 315698-78-3

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MCULE-3064932370 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MCULE-3064932370 is a covalent and allosteric SUMO E1 (heterodimer of Aos1 and Uba2) inhibitor with IC50 values ranging from 16.66 μM to 2.96 μM. MCULE-3064932370 inhibits SUMOylation of Uba2. MCULE-3064932370 has anti-cancer activity against breast cancer[1].

体外研究
(In Vitro)

MCULE-3064932370 (0-100 μM; 0-1.5 h) 可时间依赖性和浓度依赖性地抑制 SUMO E1 (Aos1/Uba2 复合物) 活性，在 0 至 1.5 小时的预孵育时间内，其 IC50 值范围为 16.66 ± 9.55 μM 至 2.96 ± 1.61 μM[1]。
MCULE-3064932370 (0.1-100 μM; 24-48 h) 可浓度依赖性地抑制 T47D 乳腺癌细胞增殖，其 24 h 时的 EC50 值为 20.79 ± 3.26 μM，48 h 时的 EC50 值为 10.40 ± 4.58 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MCULE-3064932370 相关抗体:

Cell Migration Assay[1]

Cell Line: Human T47D breast cancer cells
Concentration: 12.5 μM, 25 μM
Incubation Time: 24 h
Result: Reduced relative cell migration to 0.54 (12.5 μM) and 0.32 (25 μM) of vehicle control.
分子量

368.43

Formula

C18H12N2O3S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MCULE-3064932370 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MCULE-3064932370315698-78-3MCULE3064932370MCULE 3064932370E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseUba2 Cys30SUMO E1 (Aos1/Uba2 heterodimer)CEP44polyamine synthesisSUMOylation pathwaybreast cancerT47D breast cancer cellsSUMO1RanGAP1MAT2AInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-181772
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