2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Meglitinide

Meglitinide 是一种 ATP 敏感性钾 (KATP) 通道抑制剂，对含 SUR1、SUR2A 和 SUR2B 的 KATP 通道的 IC50 值分别为 0.26 μM、0.53 μM 和 1.6 μM，对 SUR1 和 SUR2A 的 Kd 值均为 7 μM，对 SUR2B 的 Kd 值为 8 μM。Meglitinide 可高亲和力结合 SUR1、SUR2A 和 SUR2B 亚基以关闭 KATP 通道，作用于所有 SUR 亚型共有的结合位点，且与携带 S1237Y 突变的 SUR1 的相互作用未发生改变。Meglitinide 可用于 2 型糖尿病的相关研究。

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Meglitinide

Meglitinide Chemical Structure

CAS No. : 54870-28-9

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Meglitinide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Meglitinide is an ATP-sensitive potassium (KATP) channel inhibitor. Meglitinide exhibits IC50 values of 0.26 μM, 0.53 μM and 1.6 μM against KATP channels containing SUR1, SUR2A and SUR2B, respectively, with a Kd value of 7 μM for both SUR1 and SUR2A, and a Kd value of 8 μM for SUR2B. Meglitinide binds to the SUR1, SUR2A and SUR2B subunits with high affinity to close KATP channels, acting on a binding site shared by all SUR subtypes, and its interaction with SUR1 carrying the S1237Y mutation remains unchanged. Meglitinide is applicable to research related to type 2 diabetes[1].

体外研究
(In Vitro)

Meglitinide 可以相似的亲和力阻断重组 Kir6.2/SUR1、Kir6.2/SUR2A 和 Kir6.2/SUR2B KATP 通道，不同通道亚型对应的 IC50 值为 0.26 至 1.6 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Meglitinide 相关抗体:
分子量

333.77

Formula

C17H16ClNO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Meglitinide 相关分类

  • 摩尔计算器

  • 稀释计算器

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Keywords:

Meglitinide54870-28-9Potassium ChannelKcsAATP-sensitive potassium (K_ATP) channelpancreatic β-cellSUR2ASUR2Btype 2 diabetesKir6.2/SUR1Kir6.2/SUR2AS1237Y mutationinsulin secretionSUR1Inhibitorinhibitorinhibit

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目录号：
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