2. Protein Tyrosine Kinase/RTK Apoptosis
  3. c-Met/HGFR Apoptosis
  4. Mer/c-Met-IN-1

Mer/c-Met-IN-1 是一种强效的 Mer/c-met 双抑制剂，其 IC50 值分别为 1 nM和 19 nM。Mer/c-Met-IN-1 能够抑制癌细胞的增殖、迁移并诱导凋亡 (apoptosis)。Mer/c-Met-IN-1 可用于癌症研究，如结肠癌。

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Mer/c-Met-IN-1

Mer/c-Met-IN-1 Chemical Structure

CAS No. : 3062159-91-2

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Mer/c-Met-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mer/c-Met-IN-1 is a potent Mer/c-met dual inhibitor with IC50 values of 1 and 19 nM. Mer/c-Met-IN-1 can inhibit cancer cells proliferation, migration and induce apoptosis. Mer/c-Met-IN-1 can be used for the research of cancer, such as colon cancer[1].

体外研究
(In Vitro)

Mer/c-Met-IN-1 对 HCT116、A2780、PC-3 癌细胞具有显著抗增殖活性，IC50 值分别为 1.01 μM、0.96 μM、3.42 μM[1]。
Mer/c-Met-IN-1 在人肝微粒体中表现出良好代谢稳定性，半衰期为 72.6 分钟，清除率为 0.05 mL/min/mg[1]。
Mer/c-Met-IN-1 对 hERG 钾通道抑制作用微弱，IC50 值大于 40 μM[1]。
Mer/c-Met-IN-1 (0.4-3.2 μM, 48 h) 以剂量依赖性方式诱导 HCT116 细胞凋亡，ED50 值为 1.368 pM[1]。
Mer/c-Met-IN-1 (0.8-20 μM, 24 h) 显著抑制 HCT116 细胞迁移[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mer/c-Met-IN-1 相关抗体:

Apoptosis Analysis[1]

Cell Line: HCT116 cells
Concentration: 0.4, 0.8, 1.6 and 3.2 μM
Incubation Time: 48 h
Result: Increased the Tunel-positive cells.
分子量

675.75

Formula

C38H38FN7O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mer/c-Met-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mer/c-Met-IN-13062159-91-2c-Met/HGFRApoptosisMerc-metapoptosiscancercolonHCT116A2780PC-3Inhibitorinhibitorinhibit

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