2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. Methyllycaconitine

Methyllycaconitine (MLA) 是一种强效、选择性强、可穿透血脑屏障的竞争性 α7nAChR 拮抗剂。Methyllycaconitine 可减轻淀粉样 β 肽诱导的 SH-SY5Y 细胞毒性。Methyllycaconitine 可预防甲基苯丙胺对小鼠纹状体的影响。Methyllycaconitine 可用于神经系统疾病的研究，例如阿尔茨海默病。

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CAS No. : 21019-30-7

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Methyllycaconitine 的其他形式现货产品:

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Methyllycaconitine 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 43 篇科研文献

In Vivo Imaging
WB
Histological Imaging/Staining
RT-PCR
In Vivo Efficacy Study

    Methyllycaconitine purchased from MCE. Usage Cited in: Adv Sci (Weinh). 2025 Aug 14:e00945.  [Abstract]

    3D reconstruction of micro-CT scanned images of the mouse alveolar bone. GTS-21 or MLA were administered in combination with EA in the LIP + SD + EA group, GTS-21 inhibited the progression of bone resorption, whereas Methyllycaconitine (MLA; 6 mg/kg; i.p. daily for 7 d) exacerbated it.

    Methyllycaconitine purchased from MCE. Usage Cited in: Adv Sci (Weinh). 2025 Aug 14:e00945.  [Abstract]

    Mouse periodontal tissues mRNA expression of pro-inflammatory-related genes IL-1β), IL-6, TNF-α, and anti-inflammatory-related gene IL-10. LIP+SD (LIP with sleep deprivation); EA (10 Hz, 1 mA, square wave) ; GTS-21 (4 mg/kg; i.p. daily for 7 d); Methyllycaconitine (MLA; 6 mg/kg; i.p. daily for 7 d).

    Methyllycaconitine purchased from MCE. Usage Cited in: Diabetologia. 2025 Dec 15.  [Abstract]

    Immunoblot analysis of α7nAChR after co-IP with an anti-VDAC1 antibody in HTR8/SVneo cells treated with NG (Normal glucose), HG (High glucose), HG + PNU-282987 or HG + MLA (Methyllycaconitine; 24 h).

    Methyllycaconitine purchased from MCE. Usage Cited in: Acta Pharmacol Sin. 2024 Jul;45(7):1349-1365.  [Abstract]

    TTC staining and quantification showing the blockade of VNS-induced reduction in infarct volume in the MLA (Methyllycaconitine; 2.5 mg/kg; i.p. 1 h before tMCAO model)-treated mice subjected to tMCAO model. Scale bar: 1.0 cm, n = 6.

    Methyllycaconitine purchased from MCE. Usage Cited in: Inflamm Res. 2023 Apr;72(4):879-892.  [Abstract]

    PNU-282987 (3 mg/kg; i.p.; single daily for consecutively 28 days) signifcantly decreases the expression levels of collagen I, collagen III, and α-SMA in myocardial infarction (MI) rats model, while Methyllycaconitine citrate (MLA; 3 mg/kg; i.p.; single daily for consecutively 28 days) increases these proteins levels.

    Methyllycaconitine purchased from MCE. Usage Cited in: J Neuroinflammation. 2021 Dec 17;18(1):291.  [Abstract]

    Immunofluorescence staining of hippocampal sections in each group rats (IL-1β). The microglia transform from ameboid form (α7nAchR(−/−) + taVNS group and Hi MLA  (Methyllycaconitine; (80 μg/kg; 1-week continuous unilaterally local infusions)) + taVNS group) to ramified state (Hi saline + taVNS). Compared with α7nAchR(−/−) + taVNS group and Hi MLA + taVNS group, the co-expression between pro-inflammatory cytokine IL-1β (green) and microglia (red) decreased in Hi saline + taVNS group. IL-1β (green), Iba-1 (red), DAPI (blue), Merge (yellow).

    Methyllycaconitine purchased from MCE. Usage Cited in: J Neuroinflammation. 2021 Dec 17;18(1):291.  [Abstract]

    The effect of α7nAchR in the hippocampus on the body mass and behavioral experiments of CUMS rats intervened by taVNS at different time points. MLA (Methyllycaconitine; 80 μg/kg; 1-week continuous unilaterally local infusions); taVNS (transcutaneous auricular vagus nerve stimulation).

    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Methyllycaconitine (MLA) is a potent, selective, CNS-penetrant, competitive α7nAChR antagonist. Methyllycaconitine alleviates amyloid-β peptides-induced cytotoxicity in SH-SY5Y cells. Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum. Methyllycaconitine can be used for neurological disease research, such as Alzheimer’s disease [1][2][3].

    IC50 & Target[1]

    α7nAChR

     

    分子量

    682.80

    Formula

    C37H50N2O10
    CAS 号
    中文名称

    甲基牛扁亭
    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献
    Cell Assay
    [1]

    Cells are plated in 96-well plates containing complete medium and cultured for 24 h. Then cells are treated with Methyllycaconitine at the indicated concentrations for specified times. After drug treatment, cell viability is measured by MTT assay. Briefly, 10 µL of the MTT solution (5 mg/mL) is added to each well and incubated for 4 h at 37°C. After removing the supernatant, 100 µL DMSO is added into each well. The absorbance is measured at 570 nm with a microplate reader. All experiments are repeated 3 times[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [2]

    Adult male Swiss CD-1 mice are used in all experiments. They are housed at 22±1°C under a 12-h light/dark cycle with free access to food and drinking water. Climbing behavior is measured. Briefly, mice of 20 to 26 g are intraperitoneally administered saline (5 mL/kg) or Methyllycaconitine (MLA) (6 mL/kg) at the beginning of the test. Twenty minutes later, the animals receive a single dose of saline or methamphetamine (METH) (1 mL/kg) subcutaneously and are placed individually, for habituation, into the experimental chamber consisting of a cylindrical cage with the wall made of plastic bars and covered with a lid. After a 20-min period of exploratory activity, stereotypy measurement is performed for a period of 30 min. Climbing behavior is scored by an observer who is blind to the drug treatment, and the time spent on climbing the wall (time during which almost two limbs are off the floor) is measured[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    Methyllycaconitine 相关分类

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Methyllycaconitine21019-30-7MLA甲基牛扁亭nAChRNicotinic acetylcholine receptorsamyloid-β peptides-induced cytotoxicitySH-SY5Ymouse striatumAlzheimer’s diseaseInhibitorinhibitorinhibit

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