2. Epigenetics
  3. METTL3
  4. METTL3-IN-13

METTL3-IN-13 是一种 METTL3 抑制剂。METTL3-IN-13 可用于下咽鳞状细胞癌、非小细胞肺癌等多种癌症研究。

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METTL3-IN-13

METTL3-IN-13 Chemical Structure

CAS No. : 3079150-70-9

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METTL3-IN-13 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

METTL3-IN-13 is a METTL3 inhibitor. METTL3-IN-13 is applicable to the research of multiple cancers such as hypopharyngeal squamous cell carcinoma and non-small cell lung cancer[1].

体外研究
(In Vitro)

METTL3-IN-13 (Compound 142) (72 h) 可强效抑制 Calu-6、A549、Fadu、HCT-116、MDA-MB-231、PANC-1、5637、DU 145、PC-3 的活力，其 IC50 ≤ 200 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

METTL3-IN-13 相关抗体:
体内研究
(In Vivo)

METTL3-IN-13 (Compound 142) (30 mg/kg，腹腔注射，每日 1 次共 20 天) 可显著抑制雌性 NSG 小鼠的皮下下咽鳞状细胞癌肿瘤生长并延长其生存期[1]。
METTL3-IN-13 (30 mg/kg，腹腔注射，每日 1 次共 50 天) 可显著延长原位非小细胞肺腺癌模型雌性 C.B-17 SCID 小鼠的生存期[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) (female, 6-7 weeks old, subcutaneous FaDu human hypopharyngeal squamous cell carcinoma implantation)[1]
Dosage: 30 mg/kg
Administration: i.p.; daily; day 5 to day 24
Result: Reduced day 24 tumor volume to ~800 mm3 (vs ~2000 mm3 in vehicle control).
Prolonged survival: 80% survived to day 32, and 20% survived to day 40 (all vehicle-treated mice died by day 24).
Animal Model: C.B-17 SCID (C.B-17/IcrHsd-Prkdcscid) (female, 6-7 weeks old, orthotopic A549-Luc-C8 human non-small cell lung adenocarcinoma implantation)[1]
Dosage: 30 mg/kg
Administration: i.p.; daily; day 16 to day 66
Result: Prolonged survival: 50% survived to day 60, and 10% survived to day 75 (all vehicle-treated mice died by day 45).
分子量

462.59

Formula

C25H34N8O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

METTL3-IN-13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

METTL3-IN-133079150-70-9METTL3Methyltransferase-like 3Calu-6 lung adenocarcinoma cellsA549 lung adenocarcinoma cellscarcinomaMDA-MB-231 breast adenocarcinoma cellsHepG2 hepatocellular carcinoma cells5637 urinary bladder carcinoma cellsPANC-1 pancreatic carcinoma cellsFaDu hypopharyngeal squamous cell carcinoma cellsHCT-116 colorectal carcinoma cellsInhibitorinhibitorinhibit

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产品名称：
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目录号：
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