2. Metabolic Enzyme/Protease
  3. Acyltransferase
  4. MGAT2-IN-7

MGAT2-IN-7 (compound 27Q) 是一种取代苯磺酰胺类化合物，同时也是单酰基甘油酰基转移酶 2 (MGAT2) 抑制剂。MGAT2-IN-7 可用于肥胖及代谢功能障碍相关脂肪性肝病 (MASLD) 的研究。

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MGAT2-IN-7

MGAT2-IN-7 Chemical Structure

CAS No. : 3115123-06-0

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MGAT2-IN-7 相关抗体

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ACAT1 ACAT2 MGAT2 ACAT DGAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MGAT2-IN-7 (compound 27Q) is a substituted benzenesulfonamide compound and also a monoacylglycerol acyltransferase 2 (MGAT2) inhibitor. MGAT2-IN-7 is used for research on obesity and metabolic dysfunction-associated steatotic liver disease (MASLD)[1].

体外研究
(In Vitro)

MGAT2-IN-7 (compound 27Q) (0.1-10 μM; 45 h) 可在体外巯基荧光酶分析实验中强效抑制人单酰基甘油酰基转移酶 2，其 IC50 值＜1 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MGAT2-IN-7 相关抗体:
体内研究
(In Vivo)

MGAT2-IN-7 (27Q)(灌胃给药，每日 1 次，连续 7 天，剂量 15-50 mg/kg) 可在饮食诱导肥胖小鼠中引发剂量依赖性体重下降并减少食物摄入，其中 50 mg/kg (灌胃给药，每日 1 次，连续 7 天) 可使小鼠体重降低 6.8%[1]。
MGAT2-IN-7 (27Q) (50 mg/kg；灌胃；每日一次；连续 22 天) 与 GLP-1 受体激动剂联用时，在饮食诱导肥胖小鼠中以 50 mg/kg (p.o., daily for 22 days) 的剂量可协同增强减重效果并减少食物摄入，其体重降低效应在第 17 天被测定[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (male, 16 weeks old, diet-induced obese)[1]
Dosage: 15 mg/kg; 50 mg/kg
Administration: p.o.; daily; 7 days
Result: Reduced average body weight by 1.39 g (3.6%) over 7 days, with 10% less 24-hour food intake and 9% less 7-day cumulative food.
Reduced average body weight by 2.5 g (6.8%) over 7 days, with 17% less 24-hour food intake and 20% less 7-day cumulative food.
Animal Model: C57BL/6J (male, diet-induced obese)[1]
Dosage: 50 mg/kg
Administration: p.o.; daily; 22 days
Result: Increased body weight reduction from -17.8% (tirzepatide alone) to -38% at 17 days and reduced cumulative food intake by 84% relative to vehicle controls (a 4-fold additional reduction over tirzepatide alone) when combined with maximum dose tirzepatide.
Increased body weight reduction from -32% (semaglutide alone) to -74.3% at 17 days and reduced cumulative food intake by 77% relative to vehicle controls (a 3.3-fold additional reduction over semaglutide alone) when combined with maximum dose semaglutide.
All differences were statistically significant.
分子量

629.65

Formula

C31H30F3N3O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MGAT2-IN-7 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MGAT2-IN-73115123-06-0AcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferasemetabolic dysfunction-associated steatotic liver diseasehuman monacylglycerol acyltransferase 2GLP-1 receptor agonistsobesitymonacylglycerol acyltransferase 2diet-induced obese miceInhibitorinhibitorinhibit

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目录号：
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