2. Others Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Biochemical Assay Reagents Reactive Oxygen Species (ROS)
  4. Mitochondrial penetrating peptide

Mitochondrial penetrating peptide 是一种肽序列 (FrFKFrFK-CONH2)，可选择性地将货物转运至线粒体。Mitochondrial penetrating peptide 具备特殊的理化性质，无需借助溶剂或膜透化处理，即可将双核 Ru (II) 多吡啶复合物选择性转运至活哺乳动物细胞的线粒体中，实现复合物的精准线粒体定位与富集，同时排除细胞核分布。Mitochondrial penetrating peptide 可通过偶联的 Ru (II) 复合物的发光寿命变化，对活哺乳动物细胞内的线粒体氧浓度及 ROS 生成进行动态监测。

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Custom Peptide Synthesis

Mitochondrial penetrating peptide

Mitochondrial penetrating peptide Chemical Structure

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Mitochondrial penetrating peptide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mitochondrial penetrating peptide is a peptide sequence (FrFKFrFK-CONH2) that selectively transports cargo into mitochondria. Mitochondrial penetrating peptide possesses special physicochemical properties, enabling it to selectively translocate dinuclear Ru (II) polypyridine complexes into mitochondria of living mammalian cells without the aid of solvents or membrane permeabilization treatments, thus achieving precise mitochondrial localization and enrichment of the complexes while excluding their distribution in the nucleus. Mitochondrial penetrating peptide enables dynamic monitoring of mitochondrial oxygen concentration and ROS production in living mammalian cells via changes in the luminescence lifetime of the coupled Ru (II) complex[1].

体外研究
(In Vitro)

Mitochondrial penetrating peptide 可将偶联的双核钌 (II) 多吡啶复合物选择性靶向至活 HeLa 细胞的线粒体，实现精准的细胞器定位，同时细胞质背景极低且无细胞核蓄积[1]。
Mitochondrial penetrating peptide 可实现偶联双核钌 (II) 多吡啶配合物以浓度和温度依赖的方式快速被活 HeLa 细胞和 CHO 细胞摄取，且该膜穿透过程依赖能量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mitochondrial penetrating peptide 相关抗体:
分子量

1174.44

Formula

C60H87N17O8
Sequence

Phe-d{Arg}-Phe-Lys-Phe-d{Arg}-Phe-Lys-NH2
Sequence Shortening

F-d{Arg}-FKF-d{Arg}-FK-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mitochondrial penetrating peptide 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mitochondrial penetrating peptideBiochemical Assay ReagentsReactive Oxygen Species (ROS)CHO cellslive mammalian cellsreactive oxygen speciesHeLa cellsdinuclear ruthenium(II) polypyridyl complexesmitochondriaInhibitorinhibitorinhibit

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